rabies | EURL

EURL rabies

URL:

https://eurl-rabies.anses.fr

Background type:

color

Intro [EN]:

Collection of samples, techniques, validation and interpretation of the diagnostic methods for the purposes of rabies surveillance are presented here.

Diagnostic methods considered compliant are presented in the WOAH rabies manual. A list of procedures inspired by the WOAH official methods is also proposed.

Title [EN]:

Diagnostic methods

Methods Background:

Materiau Background:

Code AT Internet:

624742

Nom page d'accueil (AT):

Home_EURL_Rabies

Intro [EN]:

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Inter-laboratory test for rabies diagnosis 2014

♦ 04 February 2014 ♦

Registration for participation to the inter-laboratory test for diagnosis is now over. Fifty laboratories will participate on one or more techniques (FAT, RTCIT, Conventional and/or real time RT-PCR). The samples will be sent end of May for a test performance in June 2014.

Participants will be asked to answer an online questionnaire for each technique used. It aims to compare the procedures used in laboratories and will help to highlight the influences of variations on the results obtained during the trial.

European Union Reference Laboratory team presentation

Former Workshops documents

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The Nancy laboratory for rabies and wildlife is part of ANSES.

The French Agency for Food, Environmental and Occupational Health Safety (ANSES) has incorporated the missions, resources and personnel of the French Food Safety Agency (AFSSA) and the French Agency for Environmental and Occupational Health Safety (AFSSET). Its principal mission is to contribute to the protection of human health with respect to the environment, the workplace and food.

On 1st July 2008, the European Commission designated the French Food Safety Agency as the European Union Reference Laboratory (EURL) for rabies (Regulation (EC) No 737/2008).

The activities of the European Union Reference Laboratory are undertaken in the Lyssavirus Unit of the Nancy laboratory for rabies and wildlife. This laboratory is specialised in animal rabies and several dominant and emerging wildlife zoonoses. The laboratory has 50 years of experience in rabies and is internationally recognised in this field.

Nancy laboratory for rabies and wildlife presentation on ANSES website
www.anses.fr

Last update: 25 November 2022

Contact

Duties of the European Union Reference Laboratory for Rabies

Coordinating the methods employed in the Member States for diagnosing rabies

● Typing, storing and supplying strains of rabies virus

● Preparing, controlling and supplying international standard sera and other reference reagents to the National Reference Laboratories in order to standardise the tests and reagents used in the Member States

● Validating reference reagents including antigens and national standard sera submitted by the National Reference Laboratories

● Building up and maintaining a sera bank and a collection of rabies virus, and maintaining a database of strains isolated across the European Union, including typing

● Organising periodical comparative tests of diagnostic procedures at European Union level and operating laboratory proficiency tests of National Reference Laboratories

● Collecting and collating data and information on the methods of diagnosis used and the results of tests carried out in the European Union

● Characterising rabies virus by the most up-to-date methods available to allow a greater understanding of the epidemiology of the disease

● Keeping abreast of developments in rabies surveillance, epidemiology and prevention throughout the world

● Acquiring a thorough knowledge of the preparation and use of the products of veterinary immunology used to eradicate and control rabies, including the evaluation of vaccines

Contributing to the improvement and harmonisation of methods of analysis throughout the European Union

● By specifying standard test methodologies

● By providing reference materials to NRLs

● By providing NRLs with details and guidance on the methods of laboratory analysis, testing or diagnosis

● By conducting training courses for staff from NRLs, and if needed from other official laboratories

Organising workshops for the benefit of National Reference Laboratories

● Including training of experts from the Member States and, as appropriate, from third countries, in new analytical methodologies

Providing scientific and technical assistance to the Commission

● And, upon its request, by participating in international forums relating to rabies, concerning in particular the standardisation of analytical diagnostic methods and their implementation

Performing and coordinating research activities directed towards the improved control and eradication of rabies

● Carrying out or collaborating with National Reference Laboratories in test validation trials

● Providing scientific advice to the Commission and collecting information and reports associated with the activities of the European Union Reference Laboratory

MAIN PARTNERS

European Commission www.ec.europa.eu
WOAH - World Organisation for Animal Health www.woah.org/en/home/
WHO - World Health Organisation www.who.int
EFSA - European Food Safety Authority www.efsa.europa.eu
EDQM - European Directorate for the Quality of Medicines and Healthcare www.edqm.eu
FAO - Food and Agriculture Organisation www.fao.org
GARC - Global Alliance for Rabies Control https://rabiesalliance.org/

ADDITIONAL DOCUMENTATION

...

European Commission website and regulation

Regulation (EU) 2017/625 of the European Parliament and of the Council of 15 March 2017 (Repeal of Regulation (EC) No 882/2004)
Commission Regulation (EC) No 415/2013 of 6 May 2013 (Amendment of Regulation (EC) No 737/2008)
Regulation (EC) No 208/2011 (Amendment of Annex VII to Regulation (EC) No 882/2004)
Commission Regulation (EC) No 737/2008 of 28 July 2008 (Nomination of Anses as EURL for rabies)
Regulation (EC) No 882/2004 (Official controls)
List of European Union Reference Laboratories

Last update : 17 January 2023

Other international activities

Last update: 17 January 2020

The laboratory is:

WHO Collaborating Centre for Research and Management in zoonosis control since September 1983,
WOAH Reference Laboratory for rabies since June 1991,
European Union Reference Laboratory for rabies serology since March 2000,
European Union Reference Laboratory for rabies since July 2008.
Official Medicines Control Laboratory (for inactivated and oral rabies vaccines) since 2012.

The laboratory provides scientific and technical support at the European level (European Commission, EDQM, EFSA), and to international organizations (OIE, WHO) through numerous activities. The laboratory works in close cooperation with the National Reference Laboratories and their competent authorities for helping to define the strategy and the organization of oral vaccination programmes, as well as for establishing the surveillance and the monitoring of the disease (incidence of rabies, assessment of bait uptake and of rabies immunity both in adult and young target animals).

The laboratory ensures training activities in the frame of its own programmes, and collaborates in the preparation and distribution of teaching materials.

Biological reference material and laboratory services are available on request to help international laboratories to develop their own rabies surveillance and monitoring systems, as well as any other laboratory services for rabies research and epidemiology.

The rabies laboratory's experts provide scientific and technical assistance, advice and training for Member States and third countries. They are also involved in evaluation studies for improving and adapting existing diagnostic, serological, molecular biology and epidemiological tools.

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Additional documentation

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WOAH (World Organisation for Animal Health)
WHO (World Health Organisation)
E.C (European Commission)
EFSA (European Food Safety Authority)
EDQM (European Directorate for the Quality of Medicines and Healthcare)
FAO (Food and Agriculture Organisation)
GARC (Global Alliance for Rabies Control)

Reference collection

Last update: 12/01/2023

Links

A non-exhaustive list of main partners of the network:

EU National Reference Laboratories for rabies

List of the EU National Reference Laboratories for rabies, including presentation (for private members only) and official website:

Last update: 14 january 2022

Inter-laboratory test for rabies diagnosis 2014

European Union Reference Laboratory team presentation

Former Workshops documents

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European Union Reference Laboratory EURL for rabies

Duties of the European Union Reference Laboratory for Rabies

MAIN PARTNERS

ADDITIONAL DOCUMENTATION

European Commission website and regulation

Other international activities

..

Additional documentation

..

Reference collection

Links

EU National Reference Laboratories for rabies

EURL technical evaluation

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